Pharmacogenetics

[Prof Kam's lecture notes]

Potential consequences of polymorphic drug metabolism

• Extended pharamcological effect
• Adverse drug reaction
• Lack of prodrug activation
• Increased effective dose
• Metabolisim by alternative deleterious pathways
• Drug interaction

Anaesthetic drug related

• Porphyria
• Plasma cholinesterase deficiency
• Malignant hyperthermia

Other drug

• G-6-P dehydrogenase deficiency
• Alcohol dehydrogenase deficiency
• N-Acetyl transferase
• Glucuronyl transferase
• Debrisoquine /sparteine hydroxylase (CYP2D6)