Oxygen toxicity

 

[Ref: TF8-p182]

retrolental fibroplasia

bronchopulmonary dysplasia in neonates

loss of hypoxic drive in COPD

tracheobronchial irritation

thickening of alveolar-capillary membrane with proliferation of type I pneumocytes

 

Mechanism: superoxide anions and hydroxyl free radicals

Defence: superoxide dismutase (SOD) for superoxide anions

catalase (CAT) for H2O2