Glomerulotubular balance

When GFR increases,

--> Sodium reabsorption in proximal tubule increases

--> Fraction of sodium (and thus water) reabsorbed in proximal tubule remains the same (65%)

Effect

Blunts changes in sodium excretion due to GFR changes

Comparison

• GFR autoregulation blunts changes in GFR due to changes in BP
• Tubuloglumerular feedback blunts changes in pressure natriuresis and diuresis
• Glomerulotubular balance blunts changes in sodium excretion due to changes in GFR