Importance of pH

The Davis hypothesis

All LMW and water soluble biosynthetic intermediates possess groups that completely dissociated at neurtal pH

Thus, efficient trapping of these ionised compounds in the cells/organelles

Importance of pH

pH is important for metabolism because

1. Effect on small molecules

• Intracellular trapping of intermediary metabolites
  * Davis hypothesis

2. Effect on large molecules (protein)

• Maintain optimal protein function both intracellularly and extracellularly