Atropine is not used as an anti-emetic agent due to its CVS effects
Atropine also delays gastric emptying (????class effect)
Glycopyrrolate has negligible intestinal absorption
Glycopyrrolate does NOT cross BBB
--> No central effect e.g. anti-emesis
| Hyoscine | Atropine | Glycopyrrolate | |
| Anti-emetic | ++ | + | 0 |
| Sedation /
Amnesia |
+++ | + | 0 |
| Anti-sialagogue | +++ | + | ++ |
| Mydriasis | +++ | + | 0 |
| Placental transfer | ++ | ++ | 0 |
| Bronchodilation | + | ++ | ++ |
| Tachycardia | + | +++ | ++ |