Beta-blocker can be

selective (acting on beta1 receptors (i.e. cardiac))

nonselective (acting on both beta1 and beta2)

Or

antagonists and partial agonists

 

 

Selective beta1-blockers in low doses
--> Unlikely to cause bronchospasm, decreased peripheral blood floow, or masking hypoglycemia

 

 

alpha-blockade

check with orthostatic hypotension, nasal congestion, insomnia,

 

betablocker - ??? hypoglycaemic effect

 

Propanolol - more lipophilic --> large Vd

Newer beta-blockers are more water soluble