Butyrophenone

Droperidol

Effective at doses from 0.25mg to 0.5mg

Ceiling effect at 2.5mg
* [Brisbane May 2005 course]

Sedation more pronounced than phenothiazines

CVS adverse effects

• QT prolongation
• Torsade de pointes
• Cardiac arrest
• Ventricular tachycardia

Other side-effects

• Hyperprolactinaemia
• Hypotension
  * Due to alpha1-antagonism
• Extrapyramidal effects
• Dysphoria (dose-related)
• Blackboxed in US due to possible link to sudden cardiac death
• Anti-nausea effect is greater than anti-emetic effect
  * [Brisbane May 2005 course]