1. Pharmacology
        1.6. Antiemetic
            1.6.1. Dopamine antagonist
1.6.1.3. Benzamide

Benzamides

Metoclopramide (Maxolon)

Crosses blood-brain barrier

Well-absorbed orally but bioavailability varies widely (30-90%) due to variable first-pass metabolism

Actions

D2 antagonism

Prokinetic effects on stomach

5-HT3 antagonism at high doses

 

Side-effects

Usage

Uraemia, radiation, gastrointestinal disorders, cytotoxic drugs

 



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